The rules are simple – they have to make each other laugh using costumes, props and their imaginations. You laugh, you lose.
All gloves are off as Ant drags up to become Holly and Dec channels his inner silver fox to impersonate Phillip, while Phillip also embraces his feminine side by slipping into stockings and a pair of high heels – but can either of the duos keep a straight face?
And how will Ant and Dec react when Holly paints a rather risque portrait of Phillip for their amusement?
Tune in this Saturday night from 7pm on ITV.